MK2 Inhibitors: Small Molecules and Peptides

Mitogen-activated protein kinase-activated protein kinase 2 (MK2; MAPKAPK2), EC 2.7.11.1, is a member of the MAPKAPK family of kinases, which also consists of MK3 and MK5 (PRAK). The MAPKAPK family are activated by MAPK signaling, with MK2 being a downstream substrate of p38.

MK2 is ubiquitously expressed, with its highest expression in the heart, kidney and skeletal muscle. In quiescent cells MK2 is predominantly localized to the nucleus. In response to stress stimuli (such as UV irradiation, ...