MAP2 Proteins and Enzymes

Microtubule-associated Protein 2 (MAP2) is an 1827 amino acid (aa) cytoskeletal associated protein that contains C-terminal microtubule-binding repeats and a conserved N-terminal domain, which has been shown to interact with the RII regulatory subunit of Protein Kinase A. Human MAP2 shares 84% and 79% aa identity with the mouse and rat orthologs, respectively. Multiple splice forms exist, resulting in four distinct isoforms with differing N-terminal domains.  Mammalian MAP2 is mainly ...