IRAK4: Small Molecules and Peptides
IL-1 receptor-associated kinases (IRAKs) are serine/threonine kinases that help mediate signaling from Toll-like receptor (TLR) and IL-1 receptor family members. Four human IRAKs have been identified: IRAK1, IRAK2, IRAK-M, and IRAK4. All IRAKs are multidomain proteins, containing a conserved N-terminal death domain as well as a central kinase domain that is only active in IRAK1 and IRAK4. IRAK4 mutations have been described in patients with recurrent bacterial infections and poor inflammatory responses.
3 results for "IRAK4 Small Molecules and Peptides" in Products
3 results for "IRAK4 Small Molecules and Peptides" in Products
IRAK4: Small Molecules and Peptides
IL-1 receptor-associated kinases (IRAKs) are serine/threonine kinases that help mediate signaling from Toll-like receptor (TLR) and IL-1 receptor family members. Four human IRAKs have been identified: IRAK1, IRAK2, IRAK-M, and IRAK4. All IRAKs are multidomain proteins, containing a conserved N-terminal death domain as well as a central kinase domain that is only active in IRAK1 and IRAK4. IRAK4 mutations have been described in patients with recurrent bacterial infections and poor inflammatory responses.
Potent and selective IRAK4 inhibitor
| Chemical Name: | N-[3-Aminocarbonyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-2-(2-methyl-4-pyridinyl)-4-oxazolecarboxamide hydrochloride |
| Purity: | ≥98% (HPLC) |
IRAK4 and IRAK1 inhibitor
| Chemical Name: | N-[1-[2-(4-Morpholinyl)ethyl]-1H-benzimidazol-2-yl]-3-nitrobenzamide |
| Purity: | ≥98% (HPLC) |
Potent LMTK3 inhibitor
| Chemical Name: | 6-(Pyridin-4-yl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazine |
| Purity: | ≥98% (HPLC) |
