IL-3R beta: Proteins and Enzymes

Interleukin 3 (IL-3) is a pleiotropic cytokine that can stimulate proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. IL-3 exerts its activity through binding to a specific cell surface receptor known as IL-3R. IL-3R is a heterodimeric structure composed of a 70 kDa IL-3R alpha subunit (CD123 or beta common) and a 120-140 kDa IL-3R beta subunit (CD131). CD131 also associates with the receptor for Erythropoietin, forming a ...