Ikaros: Lysates

Ikaros (also LyF1) is a 60 kDa member of the C2H2-type zinc-finger protein family. It is found in both T and B cells and serves as a context-dependent activator or repressor of genes. Human Ikaros is 519 amino acids (aa) in length. It possesses two zinc-finger domains, one at the N-terminus that contains four zinc-finger motifs (aa 117-224) and one at the C-terminus that contains two zinc-finger motifs (aa 462-514). The C-terminal motifs mediate homo- or heterodimerization, while the N-terminal ...