Histone H1.5: Proteins and Enzymes

Histones are nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber as they play a critical role in transcription regulation, DNA repair, DNA replication, and chromosomal stability. Histone H1.5 is a 207 amino acid long, 22 kDA protein encoded by the gene HIST1H1B (found on chromosome 6p22-p21.3) that lacks polyA tails and instead obtain palindromic termination elements. H1 histones are critical for the condensation of nucleosome chains into higher order ...