3 results for "Glucagon Receptor Antagonists Small Molecules and Peptides" in Products
Glucagon Receptor Antagonists: Small Molecules and Peptides
The glucagon receptor is a member of the glucagon receptor family that also includes GLP-1, GLP-2, secretin, GHRH and GIP receptors. The glucagon receptor regulates blood glucose levels via control of hepatic glycogenolysis and gluconeogenesis, and via regulation of insulin release from the β-cells of pancreatic islets.
The glucagon receptor is predominantly expressed in the pancreas, liver and kidneys, but is also found to a lesser extent in the heart, adipose tissue, spleen, thymus and adrenal glands. The human glucagon receptor gene is localized on chromosome 17q25.
Glucagon receptor antagonist
| Purity: | ≥95% (HPLC) |
Potent, orally active human glucagon receptor antagonist
| Chemical Name: | 4-[3-(5-Bromo-2-propoxyphenyl)-5-(4-chlorophenyl)-1H-pyrrol-2-yl]pyridine |
| Purity: | ≥98% (HPLC) |
Negative allosteric modulator of glucagon and GLP-1 receptors
| Chemical Name: | 4-[[(4-Cyclohexylphenyl)[[[3-(methylsulfonyl)phenyl]amino]carbonyl]amino]methyl]-N-2H-tetrazol-5-ylbenzamide |
| Purity: | ≥98% (HPLC) |
