FCRN: Proteins and Enzymes

FcRN (the neonatal Fc receptor) is a transmembrane MHC class I-like glycoprotein that is widely expressed on endothelial and epithelial cells. Mouse FcRN binds with high affinity to IgG from mouse, human, rat, rabbit, guinea pig, bovine, and sheep, while human FcRN binds IgG with significantly lower affinity and is much more restricted in terms of species recognition. It additionally binds to Albumin and beta 2-Microglobulin. FcRN is involved in recycling endocytosed IgG and Albumin, the ...