5 results for "EGFR" in Products
EGFR Products
EGFR (epidermal growth factor receptor), also known as HER-1, ErbB1, or ErbB, is a transmembrane receptor tyrosine kinase that binds a subset of the EGF family ligands including EGF, Amphiregulin, TGF-alpha, Betacellulin, Epiregulin, HB-EGF, and Epigen. Ligand binding induces EGFR homodimerization as well as heterdimerization with ErbB2, resulting in kinase activation, tyrosine phosphorylation and cell signaling. EGFR can also be recruited to form heterodimers with the ligand-activated ErbB3 or ...
Potent EGFR PROTAC® Degrader; also degrades HER2
Potent dual specificity EGFR/HER2 inhibitor; active in vivo
Selective EGFR PROTAC® Degrader
Potent and selective cereblon-recruiting Degrader (PROTAC®) of mutant EGFR
Potent and selective VHL-recruiting Degrader (PROTAC®) of mutant EGFR
