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5 results for "EGFR" in Products

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EGFR Products

EGFR (epidermal growth factor receptor), also known as HER-1, ErbB1, or ErbB, is a transmembrane receptor tyrosine kinase that binds a subset of the EGF family ligands including EGF, Amphiregulin, TGF-alpha, Betacellulin, Epiregulin, HB-EGF, and Epigen. Ligand binding induces EGFR homodimerization as well as heterdimerization with ErbB2, resulting in kinase activation, tyrosine phosphorylation and cell signaling. EGFR can also be recruited to form heterodimers with the ligand-activated ErbB3 or ...

SJF 1528

Catalog #: 7262

Citations (1)

Product Documents

Images (1)

Potent EGFR PROTAC® Degrader; also degrades HER2

Chemical Name:

(2S,4R)-1-((S)-2-(2-(2-(2-(4-(4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6- yl)phenoxy)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Purity:

≥98%

Gefitinib-based PROTAC^® 3

Catalog #: 7258

(1)

Citations (1)

Product Documents

Images (1)

Potent EGFR PROTAC® Degrader

Alternate Names:

Iressa-based PROTAC 3

Chemical Name:

(2S,4R)-1-((S)-2-(3-(2-((5-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)pentyl)oxy)ethoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Purity:

≥98%

SJF 1521

Catalog #: 7261

Citations (1)

Product Documents

Images (1)

Selective EGFR PROTAC® Degrader

Chemical Name:

(2S,4R)-1-((S)-2-(tert-Butyl)-14-(4-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)phenoxy)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Purity:

≥98%

MS 154

Catalog #: 7395

Product Documents

Images (1)

Potent and selective cereblon-recruiting Degrader (PROTAC®) of mutant EGFR

Chemical Name:

3-(4-(3-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)-N-(8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)octyl)propanamide

Purity:

≥98%

MS 39

Catalog #: 7397

Citations (1)

Product Documents

Images (1)

Potent and selective VHL-recruiting Degrader (PROTAC®) of mutant EGFR

Chemical Name:

(2S,4R)-1-((S)-2-(11-(4-(3-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)-11-oxoundecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Purity:

≥98%

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