Dopamine D3 Receptor Antagonists: Small Molecules and Peptides
DRD3 is the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. It is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variations may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing results in transcript variants encoding different isoforms. This variant represents the predominant transcript and encodes the longer isoform (a).
4 results for "Dopamine D3 Receptor Antagonists Small Molecules and Peptides" in Products
4 results for "Dopamine D3 Receptor Antagonists Small Molecules and Peptides" in Products
Dopamine D3 Receptor Antagonists: Small Molecules and Peptides
DRD3 is the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. It is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variations may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing results in transcript variants encoding different isoforms. This variant represents the predominant transcript and encodes the longer isoform (a).
D2 and D3 antagonist (D3 > D2)
| Alternate Names: | (-)-Eticlopride |
| Chemical Name: | 3-Chloro-5-ethyl-N-[[(2S)-1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxy-benzamide hydrochloride |
| Purity: | ≥99% (HPLC) |
Selective D3 antagonist
| Chemical Name: | N-[(2E)-4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]-2-buten-1-yl]-4-(2-pyridyl)-benzamide dihydrochloride |
| Purity: | ≥98% |
Potent and selective D3 antagonist
| Chemical Name: | N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide |
| Purity: | ≥98% (HPLC) |
Selective D3 antagonist
| Chemical Name: | N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide dihydrochloride |
| Purity: | ≥98% (HPLC) |
