3 results for "DNA-dependent Protein Kinase Inhibitors Small Molecules and Peptides" in Products
DNA-dependent Protein Kinase Inhibitors: Small Molecules and Peptides
DNA-dependent protein kinase (DNA-PK) is a nuclear protein serine/threonine kinase that is a molecular sensor of DNA damage. DNA-PK is involved in the ligation step of the non-homologous end joining (NHEJ) pathway of DNA double strand break (DSB) repair, V(D)J recombination and telomere stabilization.
DNA-PK is activated by phosphorylation by ATM/ATR following DNA damage and is inhibited by wortmannin. DNA-PK must be bound to DNA in order to exhibit its catalytic properties and has multiple targets including c-Abl, histone H1, c-jun, p53, c-Myc and more.
Highly potent PI 3-kinase inhibitor; also potent inhibitor of mTOR and DNA-PK
| Alternate Names: | GSK2126458 |
| Chemical Name: | 2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide |
| Purity: | ≥98% (HPLC) |
Potent and selective DNA-PK inhibitor
| Alternate Names: | KU 57788 |
| Chemical Name: | 8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one |
| Purity: | ≥98% (HPLC) |
Potent and selective DNA-PK inhibitor; enhances CRISPR-mediated HDR efficiency
| Chemical Name: | 7,9-Dihydro-7-methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-8H-purin-8-one |
| Purity: | ≥98% (HPLC) |
