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7 results for "CTLA-4 Proteins and Enzymes" in Products
CTLA-4 Proteins and Enzymes
CTLA-4/CD152 (Cytotoxic T-Lymphocyte Antigen 4) is a transmembrane T cell inhibitory molecule that is expressed as a covalent homodimer. CTLA-4 is recruited from intracellular vesicles to the immunological synapse beginning 1-2 days after T cell activation. It forms a linear lattice with B7-1 on APC, inducing negative regulatory signals and ending CD28-dependent T cell activation. Mice deleted for CTLA-4 develop lethal autoimmune reactions due to continued T cell activation and poor control by regulatory T cells which constitutively express CTLA-4.
Reactivity:
Human
Source:
Sf 21 (baculovirus)
Accession #:
Q6GR94
Applications:
Bioactivity
Reactivity:
Human
Source:
CHO
Accession #:
P16410
Applications:
Bioactivity
Reactivity:
Mouse
Source:
NS0
Accession #:
Q6GTR6
Applications:
Bioactivity
Biotinylated
Reactivity:
Human
Source:
HEK293
Accession #:
P16410.3
Applications:
Bioactivity
Reactivity:
Canine
Source:
CHO
Accession #:
NP_001003106.1
Applications:
Bioactivity
Reactivity:
Cynomolgus Monkey
Source:
HEK293
Accession #:
XP_005574071
Applications:
Bioactivity
Reactivity:
Human
Source:
E. coli
Applications:
PAGE
![SDS-PAGE: Recombinant Human CTLA-4 His Protein [NBP2-22987]](https://resources.rndsystems.com/images/products/CTLA4-Protein-SDS-Page-NBP2-22987-img0001.jpg "SDS-PAGE: Recombinant Human CTLA-4 His Protein [NBP2-22987]")