B18R Antibodies

B18R is an IFN decoy receptor for type I IFNs encoded by the Vaccinia virus genome and by the genomes of other orthopoxviruses. It is known as B19R in the Copenhagen strain of Vaccinia and as B18R in the Western Reserve (WR) strain. B18R binds to type I IFN from multiple species and prevents IFN signaling through its receptors. B18R binds to the surface of virus infected and uninfected cells where it retains its capacity to bind and neutralize IFN. It shields those cells from the antiviral ...