AP-2 gamma Proteins and Enzymes

AP-2γ (Activation protein 2γ, also ERF-1) is a 50 - 55 kDa member of the AP-2 transcription factor family. It is essential for kidney development and placentation of the embryo. In the nucleus, it forms homodimers and heterodimers with other AP-2 family members. Elevated AP-2 family members are highly suggestive of neoplasia. Human AP-2γ is 450 amino acids in length. It contains a repressor SUMOylation site at Lys10, a Gln/Pro-rich transactivation domain (aa 30 - 119) and a ...