AP-2 epsilon: Proteins and Enzymes

Activating protein 2 epsilon (AP-2 epsilon) is a 48 kDa member of the AP-2 transcription factor family. It is found in embryonic olfactory bulb mitral cells and adult keratinocytes and chondrocytes. In the nucleus, it presumably forms homodimers and heterodimers with other AP-2 family members. Human AP-2 epsilon is 442 amino acids in length. It contains a Gln/Pro-rich transactivation domain (aa 22 - 122), a DNA binding domain (aa 216 - 286) and an AP-2, helix-span-helix dimerization region (aa 287 - 417). There is one potential alternate start site at Met09. Over aa 123 - 217, human AP-2 epsilon shares 86% aa identity with mouse AP-2 epsilon.