Alkaline Phosphatase/ALPL Proteins and Enzymes

ALPL, also known as tissue-non specific isozyme precursor, is related to, but distinct from, intestinal/ALPI, placental/ALPP, and placental-like/ALPPL2 Alkaline Phosphatases. ALPL is expressed at very high levels in undifferentiated human and mouse embryonic stem cells, embryonic carcinoma cells, and embryonic germ cells. Mutations in this enzyme have been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects.