Mandi
Tocris Bioscience, part of Bio-Techne | Catalog # 7681
Highly efficient chemical inducer of proximity (CIP)
Key Product Details
Description
Highly efficient chemical inducer of proximity (CIP)
Product Description
Mandi is a chemical inducer of proximity (CIP) in vivo and in vitro (EC50 = 0.43 μM in a luciferase gene expression assay). Mandi induces complex formation between PYR1Mandi, a mutant of Abscisic Acid (Cat. No. 6554) receptor PYR1, and Abscisic Acid insensitive (ABI). Mandi may be used to induce protein colocalization and interaction. It is non-toxic, orthogonal to mammalian processes and other CIPs, and highly cell permeable.Product Specifications
Molecular Weight
411.88
Formula
C23H22ClNO4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-Chloro-N-[2-[3-methoxy-4-(2-propyn-1-yloxy)phenyl]ethyl]-α-(2-propyn-1-yloxy)benzeneacetamide
CAS Number
374726-62-2
PubChem ID
11292824
InChI Key
KWLVWJPJKJMCSH-UHFFFAOYSA-N
SMILES
C#CCOC(C=CC(CCNC(C(C1=CC=C(C=C1)Cl)OCC#C)=O)=C2)=C2OC
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.19 | 100 |
Preparing Stock Solutions
for Mandi
The following data is based on the product molecular weight 411.88
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.43 mL | 12.14 mL | 24.28 mL |
| 5 mM | 0.49 mL | 2.43 mL | 4.86 mL |
| 10 mM | 0.24 mL | 1.21 mL | 2.43 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.49 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Park An orthogonalized PYR1-based CID module with reprogrammable ligand-binding specificity. Nat.Chem.Biol. 2023 PMID: 37872402
- Ziegler Mandipropamid as a chemical inducer of proximity for in vivo applications. Nat.Chem.Biol. 2022 PMID: 34934192
Product Specific Notices for Mandi
For research use only
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