L-Azidonorleucine hydrochloride

Name: L-Azidonorleucine hydrochloride
Brand: Tocris Bioscience
SKU: 6585

Tocris Bioscience, part of Bio-Techne | Catalog # 6585

Citations (2)

COA / SDS

Unnatural amino acid for bio-orthogonal or fluorescent labeling of newly synthesized proteins

Key Product Details

Description:	Unnatural amino acid for bio-orthogonal or fluorescent labeling of newly synthesized proteins
Chemical Name:	(S)-2-Amino-6-azidohexanoic acid hydrochloride
Molecular Weight:	208.65

View Full Technical Details for L-Azidonorleucine hydrochloride

Technical Data
Citations

Biological Activity for L-Azidonorleucine hydrochloride

L-Azidonorleucine hydrochloride is an unnatural amino acid; methionine surrogate. Can be incorporated into proteins by a mutant methionyl tRNA synthetase to enable cell-type specific analysis of protein synthesis. For use with bio-orthogonal non-canonical amino-acid tagging (BONCAT) or fluorescent non-canonical amino acid tagging (FUNCAT). Labeling does not affect the normal localization of the labeled proteins.

Technical Data for L-Azidonorleucine hydrochloride

M. Wt	208.65
Formula	C₆H₁₂N₄O₂.HCl
Storage	Store at -20°C
CAS Number	1454334-76-9
PubChem ID	121235322
InChi Key	RCEAACZNVVRXSJ-JEDNCBNOSA-N
Smiles	N[C@H](C(O)=O)CCCCN=[N+]=[N-].Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L-Azidonorleucine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	20.86	100

Preparing Stock Solutions for L-Azidonorleucine hydrochloride

The following data is based on the product molecular weight 208.65.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.79 mL	23.96 mL	47.93 mL
5 mM	0.96 mL	4.79 mL	9.59 mL
10 mM	0.48 mL	2.40 mL	4.79 mL
50 mM	0.10 mL	0.48 mL	0.96 mL

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Reconstitution Calculator

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References for L-Azidonorleucine hydrochloride

References are publications that support the biological activity of the product.

Mahdavi Engineered aminoacyl-tRNA synthetase for cell-selective analysis of mammalian protein synthesis. J.Am.Chem.Soc. 2016 PMID: 26991063
Alvarez-Castelao Cell-type-specific metabolic labeling of nascent proteomes in vivo. Nat.Biotechnol. 2017 PMID: 29106408