BTD S-sulfenic acid probe

Name: BTD S-sulfenic acid probe
Brand: Tocris Bioscience
SKU: 8059

Tocris Bioscience, part of Bio-Techne | Catalog # 8059

COA / SDS

Chemoproteomic reagent for targeting S-sulfenic acids on SulfenQ platform, alkyne handle for click chemistry

Key Product Details

Description:	Chemoproteomic reagent for targeting S-sulfenic acids on SulfenQ platform, alkyne handle for click chemistry
Chemical Name:	1-(4-Pentyn-1-yl)-1H-2,1-benzothiazin-4(3H)-one 2,2-dioxide
Purity:	≥98% (HPLC)
Molecular Weight:	263.31

View Full Technical Details for BTD S-sulfenic acid probe

Technical Data
Citations

Biological Activity for BTD S-sulfenic acid probe

BTD S-sulfenic acid probe is a nucleophilic fragment that can selectively modify sulfenic acid residues in proteins, and can be used as a tool to identify ligandable S-sulfenation sites. Covalently modifies oxidized cysteines on proteins. Quantitatively labels hyper-reactive sulfenic acids at low BTD concentrations, less reactive sites exhibit concentration-dependent increases in probe labeling. Incorporates an alkyne handle for click chemistry and chemoproteomic profiling.

Technical Data for BTD S-sulfenic acid probe

M. Wt	263.31
Formula	C₁₃H₁₃NO₃S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2095485-22-4
PubChem ID	155551901
InChi Key	GSSKUKMXWRNMFK-UHFFFAOYSA-N
Smiles	O=C1C2=C(N(S(=O)(C1)=O)CCCC#C)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BTD S-sulfenic acid probe

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	26.33	100
	ethanol	5.27	20

Preparing Stock Solutions for BTD S-sulfenic acid probe

The following data is based on the product molecular weight 263.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.80 mL	18.99 mL	37.98 mL
5 mM	0.76 mL	3.80 mL	7.60 mL
10 mM	0.38 mL	1.90 mL	3.80 mL
50 mM	0.08 mL	0.38 mL	0.76 mL

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References for BTD S-sulfenic acid probe

References are publications that support the biological activity of the product.

Gupta Diverse redoxome reactivity profiles of carbon nucleophiles. J.Am.Chem.Soc. 2017 PMID: 28355876
Fu Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat.Chem.Biol. 2023 PMID: 37248412