BTD S-sulfenic acid probe
Tocris Bioscience, part of Bio-Techne | Catalog # 8059
Chemoproteomic reagent for targeting S-sulfenic acids on SulfenQ platform, alkyne handle for click chemistry
Key Product Details
Description
Chemoproteomic reagent for targeting S-sulfenic acids on SulfenQ platform, alkyne handle for click chemistry
Product Description
BTD S-sulfenic acid probe is a nucleophilic fragment that can selectively modify sulfenic acid residues in proteins, and can be used as a tool to identify ligandable S-sulfenation sites. Covalently modifies oxidized cysteines on proteins. Quantitatively labels hyper-reactive sulfenic acids at low BTD concentrations, less reactive sites exhibit concentration-dependent increases in probe labeling. Incorporates an alkyne handle for click chemistry and chemoproteomic profiling.Optical Data
| Extinction Coefficient (ε) | 1700 M-1cm-1 |
Product Specifications
Molecular Weight
263.31
Formula
C13H13NO3S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
1-(4-Pentyn-1-yl)-1H-2,1-benzothiazin-4(3H)-one 2,2-dioxide
CAS Number
2095485-22-4
PubChem ID
155551901
InChI Key
GSSKUKMXWRNMFK-UHFFFAOYSA-N
SMILES
O=C1C2=C(N(S(=O)(C1)=O)CCCC#C)C=CC=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.33 | 100 | |
| Ethanol | 5.27 | 20 |
Preparing Stock Solutions
for BTD S-sulfenic acid probe
The following data is based on the product molecular weight 263.31
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.80 mL | 18.99 mL | 37.98 mL |
| 5 mM | 0.76 mL | 3.80 mL | 7.60 mL |
| 10 mM | 0.38 mL | 1.90 mL | 3.80 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.76 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Gupta Diverse redoxome reactivity profiles of carbon nucleophiles. J.Am.Chem.Soc. 2017 PMID: 28355876
- Fu Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat.Chem.Biol. 2023 PMID: 37248412
Product Specific Notices for BTD S-sulfenic acid probe
For research use only
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