Chicago Sky Blue 6B
Tocris Bioscience, part of Bio-Techne | Catalog # 0846
Dye used as counterstain in histochemistry; also potent inhibitor of L-glutamate uptake into synaptic vesicles; also inhibits MIF
Discontinued Product
0846 has been discontinued.
View all Glutamate (EAAT) Transporter Inhibitors products.
Key Product Details
Description
Dye used as counterstain in histochemistry; also potent inhibitor of L-glutamate uptake into synaptic vesicles; also inhibits MIF
Product Description
Chicago Sky Blue 6B is a potent inhibitor of L-glutamate uptake into synaptic vesicles. Allosterically inhibits macrophage migration inhibitory factor (MIF) (IC50 = 0.81 μM); inhibits MIF proinflammatory activity. Also dye used as counterstain in histochemistry.Product Specifications
Molecular Weight
992.79
Formula
C34H24N6Na4O16S4
Storage
Store at RT
Chemical Name
6,6'-[(3,3-Dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-amino-5-hydroxy-1,3-napthalenedisulphonic acid] tetrasodium salt
CAS Number
2610-05-1
PubChem ID
102063628
InChI Key
BPHHNXJPFPEJOF-UHFFFAOYSA-J
SMILES
[Na+].[Na+].[Na+].[Na+].COC1=CC(=CC=C1\N=N\C1=C(O)C2=C(C=C1)C(=CC(=C2N)S([O-])(=O)=O)S([O-])(=O)=O)C1=CC(OC)=C(C=C1)\N=N\C1=C(O)C2=C(N)C(=CC(=C2C=C1)S([O-])(=O)=O)S([O-])(=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 99.28 | 100 |
Preparing Stock Solutions
for Chicago Sky Blue 6B
The following data is based on the product molecular weight 992.79
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.01 mL | 5.04 mL | 10.07 mL |
| 5 mM | 0.20 mL | 1.01 mL | 2.01 mL |
| 10 mM | 0.10 mL | 0.50 mL | 1.01 mL |
| 50 mM | 0.02 mL | 0.10 mL | 0.20 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Fonnum Inhibitors of amino acid uptake into vesicles. J.Neurochem.
- Bai A novel allosteric inhibitor of macrophage migration inhibitory factor (MIF). J.Biol.Chem. 2012 PMID: 22782901
- Roseth Uptake of L-glutamate into rat brain synaptic vesicles: effect of inhibitors that bind specifically to the glutamate transport. J.Neurochem. 1995 PMID: 7790899
Product Specific Notices for Chicago Sky Blue 6B
For research use only
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