ZQ 16
Tocris Bioscience, part of Bio-Techne | Catalog # 6001
Selective GPR84 agonist
Discontinued Product
6001 has been discontinued.
View all Free Fatty Acid Receptor Agonists products.
Key Product Details
Description
Selective GPR84 agonist
Product Description
ZQ 16 is a selective medium-chain free fatty acid receptor GPR84 agonist (EC50 = 139 nM). Exhibits no response at GPR40, GPR41, GPR119 or GPR120 at 100 μM. Activates calcium mobilization, inhibits cAMP accumulation, and induces ERK1/2 phosphorylation, receptor desensitization and internalization in vitro.Product Specifications
Molecular Weight
228.31
Formula
C10H16N2O2S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-(Hexylthio)-6-hydroxy-4(3H)-pyrimidinone
CAS Number
376616-73-8
PubChem ID
1912564
InChI Key
UYXOAKRMLQKLQX-UHFFFAOYSA-N
SMILES
CCCCCCSC1=NC(O)=CC(N1)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 11.42 | 50 | |
| Ethanol | 22.83 | 100 |
Preparing Stock Solutions
for ZQ 16
The following data is based on the product molecular weight 228.31
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.38 mL | 21.90 mL | 43.80 mL |
| 5 mM | 0.88 mL | 4.38 mL | 8.76 mL |
| 10 mM | 0.44 mL | 2.19 mL | 4.38 mL |
| 50 mM | 0.09 mL | 0.44 mL | 0.88 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zhang Discovery and characterization of a novel small-molecule agonist for medium-chain free fatty acid receptor G protein-coupled receptor 84. J.Pharmacol.Exp.Ther. 2016 PMID: 26962172
- Liu Design and synthesis of 2-alkylpyrimidine-4,6-diol and 6-alkylpyridine-2,4-diol as potent GPR84 agonists. ACS Med.Chem.Lett. 2016 PMID: 27326330
Product Specific Notices for ZQ 16
For research use only
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