ZM 323881 hydrochloride

Name: ZM 323881 hydrochloride
Brand: Tocris Bioscience
SKU: 2475

Tocris Bioscience, part of Bio-Techne | Catalog # 2475

Citations (14)

COA / SDS

Potent, selective inhibitor of VEGFR-2

Key Product Details

Description:	Potent, selective inhibitor of VEGFR-2
Chemical Name:	5-((7-Benzyloxyquinazolin-4-yl)amino)-4-fluoro-2-methylphenol hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	411.86

View Full Technical Details for ZM 323881 hydrochloride

Technical Data
Citations

Biological Activity for ZM 323881 hydrochloride

ZM 323881 hydrochloride is a potent and selective inhibitor of human vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) activity. Selectively inhibits VEGFR-2 (IC₅₀ = 2 nM) over VEGFR-1 and a range of other receptor tyrosine kinases such as PDGFRβ, FGFR1, EGFR and erbB2 (IC₅₀ > 50 μM). Inhibits VEGF-A-induced endothelial cell proliferation in vitro (IC₅₀ = 8 nM).

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Compound Libraries for ZM 323881 hydrochloride

ZM 323881 hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for ZM 323881 hydrochloride

M. Wt	411.86
Formula	C₂₂H₁₈FN₃O₂.HCl
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	193000-39-4
PubChem ID	22624897
InChi Key	AVRHWGLIYGJSOD-UHFFFAOYSA-N
Smiles	Cl.CC1=C(O)C=C(NC2=C3C=CC(OCC4=CC=CC=C4)=CC3=NC=N2)C(F)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ZM 323881 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	20.59	50

Preparing Stock Solutions for ZM 323881 hydrochloride

The following data is based on the product molecular weight 411.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.86 mL	24.28 mL	48.56 mL
2.5 mM	0.97 mL	4.86 mL	9.71 mL
5 mM	0.49 mL	2.43 mL	4.86 mL
25 mM	0.10 mL	0.49 mL	0.97 mL

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References for ZM 323881 hydrochloride

References are publications that support the biological activity of the product.

Endo Selective inhibition of vascular endothelial growth factor receptor-2 (VEGFR-2) identifies a central role for VEGFR-2 in human aortic endothelial cell responses to VEGF. J.Recept.Signal Transduct.Res. 2003 PMID: 14626450
Whittles ZM323881, a novel inhibitor of vascular endothelial growth factor-receptor-2 tyrosine kinase activity. Microcirculation 2002 PMID: 12483548