ZLN 024 hydrochloride

Name: ZLN 024 hydrochloride
Brand: Tocris Bioscience
SKU: 5285

Tocris Bioscience, part of Bio-Techne | Catalog # 5285

Citations (4)

COA / SDS

Allosteric AMPK activator

Discontinued Product

5285 has been discontinued. View all AMPK Activators products.

Key Product Details

Description:	Allosteric AMPK activator
Chemical Name:	2-[[2-(2-Bromo-4-methylphenoxy)ethyl]thio]pyrimidine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	361.69

View Full Technical Details for ZLN 024 hydrochloride

Technical Data
Citations

Biological Activity for ZLN 024 hydrochloride

ZLN 024 hydrochloride is an allosteric AMP-activated protein kinase (AMPK) activator; allosterically stimulates active AMPK heterotrimers, increasing the activity of α1β1γ1 by 1.5-fold and α2β1γ1 by 1.7-fold (EC₅₀ values are 0.42 and 0.95 μM, respectively). Inhibits dephosphorylation of AMPK Thr-172 by PP2Cα. Stimulates glucose uptake and fatty acid oxidation without increasing the ADP/ATP ratio. Also decreases fatty acid synthesis and glucose output in primary hepatocytes. Improves glucose tolerance and decreases cholesterol content in db/db mice.

Technical Data for ZLN 024 hydrochloride

M. Wt	361.69
Formula	C1₃H₁₃BrN₂OS.HCl
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	1883548-91-1
PubChem ID	91654626
InChi Key	MMQCYIMDROWWFE-UHFFFAOYSA-N
Smiles	BrC1=C(OCCSC2=NC=CC=N2)C=CC(C)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for ZLN 024 hydrochloride

References are publications that support the biological activity of the product.

Zhang Novel small-molecule AMP-activated protein kinase allosteric activator with beneficial effects in db/db mice. PLoS One 2013 PMID: 23977216
Li Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice. Toxicol.Appl.Pharmacol. 2013 PMID: 24055643

ZLN 024 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 5285

Key Product Details

Biological Activity for ZLN 024 hydrochloride

Technical Data for ZLN 024 hydrochloride

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for ZLN 024 hydrochloride

Product Documents for ZLN 024 hydrochloride

COA

Certificate of Analysis

SDS

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