Zileuton
Tocris Bioscience, part of Bio-Techne | Catalog # 3308
5-LOX inhibitor; orally bioavailable
Key Product Details
Description
5-LOX inhibitor; orally bioavailable
Alternative Names
ICI D2138
Product Description
Zileuton is an orally active 5-lipoxygenase (5-LOX) inhibitor that inhibits LTB4 synthesis (IC50 values are 0.56, 2.3 and 2.6 μM in dog, rat and human blood respectively). Inhibits antigen-induced contraction of tracheal strips in vitro (IC50 = 6 μM) and exhibits antiasthmatic activity in vivo. Also weakly inhibits CYP1A2 (Ki = 66 - 98 μM). Ferroptosis inhibitor.Product Specifications
Molecular Weight
236.29
Formula
C11H12N2O2S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyurea
CAS Number
111406-87-2
PubChem ID
60490
InChI Key
MWLSOWXNZPKENC-UHFFFAOYSA-N
SMILES
CC(N(O)C(N)=O)C2=CC1=CC=CC=C1S2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.63 | 100 |
Preparing Stock Solutions
for Zileuton
The following data is based on the product molecular weight 236.29
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.23 mL | 21.16 mL | 42.32 mL |
| 5 mM | 0.85 mL | 4.23 mL | 8.46 mL |
| 10 mM | 0.42 mL | 2.12 mL | 4.23 mL |
| 50 mM | 0.08 mL | 0.42 mL | 0.85 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Xie Ferroptosis: process and function. Cell Death Differ. 2016 PMID: 26794443
- Malo The 5-lipoxygenase inhibitory activity of zil. in in vitro and in vivo models of antigen-induced airway anaphylaxis. Pulm.Pharmacol. 1994 PMID: 8081074
- Lu Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor. Drug Metab.Dispos. 2003 PMID: 14570767
- McMillan Pre-clinical pharmacology of ICI D2138, a potent orally-active non-redox inhibitor of 5-lipoxygenase. Br.J.Pharmacol. 1992 PMID: 1334748
Product Specific Notices for Zileuton
For research use only
⚠ WARNING: This product can expose you to chemicals including Zileuton , which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
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