ZE 132
Tocris Bioscience, part of Bio-Techne | Catalog # 7533
Potent and selective PD-1/PD-L1 interaction inhibitor
Key Product Details
Description
Potent and selective PD-1/PD-L1 interaction inhibitor
Product Description
ZE 132 binds to programmed cell death-ligand 1 (PD-L1) with high affinity (KD = 19.36 nM); it potently and selectively inhibits the interaction between programmed cell death-1 (PD-1) and PD-L1 (IC50 = 23.49 nM). ZE 132 promotes CD8+ T cell activation and improves the in vitro cytotoxic killing activity of T-cells. ZE 132 treatment can increase Cxcl9 mRNA expression and lower Tgfb1 mRNA expression in CT26 mouse colorectal cancer model. ZE 132 shows antitumor effects, inhibiting growth of CT26 tumors in mice by 64%.Product Specifications
Molecular Weight
721.27
Formula
C37H41ClN4O7S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-[[[5-Chloro-2-[(5-cyano-3-pyridinyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]phenyl]methyl][3-(dimethylamino)propyl]amino]ethanesulfonic acid
CAS Number
2566710-63-0
PubChem ID
155367962
InChI Key
QJSJWFVBDAPNAE-UHFFFAOYSA-N
SMILES
CN(CCCN(CC1=C(C=C(C(Cl)=C1)OCC2=CC=CC(C3=CC=C4OCCOC4=C3)=C2C)OCC5=CN=CC(C#N)=C5)CCS(O)(=O)=O)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 72.13 | 100 |
Preparing Stock Solutions
for ZE 132
The following data is based on the product molecular weight 721.27
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.39 mL | 6.93 mL | 13.86 mL |
| 5 mM | 0.28 mL | 1.39 mL | 2.77 mL |
| 10 mM | 0.14 mL | 0.69 mL | 1.39 mL |
| 50 mM | 0.03 mL | 0.14 mL | 0.28 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Liu Discovery of a novel, potent and selective small-molecule inhibitor of PD-1/PD-L1 interaction with robust in vivo anti-tumour efficacy. Br.J.Pharmacol. 2021 PMID: 33768523
Product Specific Notices for ZE 132
For research use only
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