ZD 7155 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 1211

Selective non-peptide AT1 antagonist
Discontinued Product
1211 has been discontinued. View all Angiotensin AT1 Receptor Antagonists products.

Key Product Details

Description

Selective non-peptide AT1 antagonist

View all Angiotensin AT1 Receptor Antagonists »

Product Description

ZD 7155 hydrochloride is a potent and selective competitive antagonist for the angiotensin II type 1 (AT1) receptor. Displaces [125I]-angiotensin II binding with an IC50 value of 3.8 nM in guinea pig adrenal gland membranes. Orally active, and is more potent and longer-acting than the prototype AT1 antagonist, losartan.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Product Specifications

Molecular Weight

474.99

Formula

C26H26N6O.HCl

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

5,7-Diethyl-3,4-dihydro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride

CAS Number

146709-78-6

PubChem ID

9826191

InChI Key

NAGGAAHTUXEGFG-UHFFFAOYSA-N

SMILES

Cl.CCC1=CC2=C(CCC(=O)N2CC2=CC=C(C=C2)C2=CC=CC=C2C2=NN=NN2)C(CC)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 4.75 10 with gentle warming

Preparing Stock Solutions for ZD 7155 hydrochloride

The following data is based on the product molecular weight 474.99

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.05 mL 105.27 mL 210.53 mL
0.5 mM 4.21 mL 21.05 mL 42.11 mL
1 mM 2.11 mL 10.53 mL 21.05 mL
5 mM 0.42 mL 2.11 mL 4.21 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for ZD 7155 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ZD 7155 hydrochloride

For research use only

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