Z-VAD-FMK
Tocris Bioscience, part of Bio-Techne | Catalog # 2163
Cell-permeable, irreversible caspase inhibitor
Key Product Details
Description
Cell-permeable, irreversible caspase inhibitor
Product Description
Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.Product Specifications
Molecular Weight
467.49
Formula
C22H30FN3O7
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone
CAS Number
634911-81-2
PubChem ID
5497174
InChI Key
MIFGOLAMNLSLGH-SXUUOERCSA-N
SMILES
[H]N(C(OCC1=CC=CC=C1)=O)[C@H](C(N[C@H](C(NC(C(CF)=O)CC(OC)=O)=O)C)=O)C(C)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 9.35mg/ml in DMSO |
Calculators
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Background References
References are publications that support the biological activity of the product.
- King Processing/activation of caspases, -3 and -7 and -8 but not caspase-2, in the induction of apoptosis in B-chronic lyphocytic leukemia cells. Leukemia 1998 PMID: 9766499
- Kunstle ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-α. Immunol.Lett. 1997 PMID: 9093874
- Garcia-Calvo Inhibition of human caspases by peptide-based and macromolecular inhibitors. J.Biol.Chem. 1998 PMID: 9829999
- Slee Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32. Biochem.J. 1996 PMID: 8670109
Product Specific Notices for Z-VAD-FMK
For research use only
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