Z-Cyclopentyl-AP4

Name: Z -Cyclopentyl-AP4
Brand: Tocris Bioscience
SKU: 3249

Tocris Bioscience, part of Bio-Techne | Catalog # 3249

COA / SDS

Group III mGlu agonist (mGlu4 > mGlu8 > mGlu7)

Discontinued Product

3249 has been discontinued. View all Group III mGluR Agonists products.

Key Product Details

Description:	Group III mGlu agonist (mGlu₄ > mGlu₈ > mGlu₇)
Chemical Name:	cis-(±)-1-Amino-3-phosphonocyclopentane carboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	209.14

View Full Technical Details for Z-Cyclopentyl-AP4

Technical Data
Citations

Biological Activity for Z-Cyclopentyl-AP4

Z-Cyclopentyl-AP4 is a group III mGlu receptor agonist that exhibits higher potency at mGlu₄ than mGlu₈ (EC₅₀ values are 49 and 124 μM respectively) with no activity at mGlu₇. Selectively inhibits synaptic activity in the lateral perforant pathway (IC₅₀ values are 130 and 1859 μM in the lateral and medial perforant pathways respectively). Conformationally restrained analog of L-AP4 (Cat No. 0103).

Technical Data for Z-Cyclopentyl-AP4

M. Wt	209.14
Formula	C₆H₁₂NO₅P
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	103439-17-4
PubChem ID	56972223
InChi Key	GLBQBTFFQHNHGC-RPBIHNRISA-N
Smiles	[H][C@@]1(CC[C@@](N)(C1)C(O)=O)P(O)(O)=O.[H][C@]1(CC[C@](N)(C1)C(O)=O)P(O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Z-Cyclopentyl-AP4

References are publications that support the biological activity of the product.

Ayala Group III mGluR regulation of synaptic transmission at the SC-CA1 synapse is developmentally regulated. Neuropharmacology 2008 PMID: 18255102
Jones Metabotropic glutamate receptors mGluR4 and mGluR8 regulate transmission in the lateral olfactory tract-piriform cortex synpase. Neuropharmacology 2008 PMID: 18625254
Crooks Cyclic analogues of 2-amino-4-phosphonobutanoic acid (APB) and their inhibition of hippocampal excitatory transmission and displacement of [³H]APB binding. J.Med.Chem. 1986 PMID: 3020251

Z-Cyclopentyl-AP4

Tocris Bioscience, part of Bio-Techne | Catalog # 3249

Key Product Details

Biological Activity for Z-Cyclopentyl-AP4

Technical Data for Z-Cyclopentyl-AP4

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Z-Cyclopentyl-AP4

Product Documents for Z-Cyclopentyl-AP4

COA

Certificate of Analysis

SDS

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