YM 750

Name: YM 750
Brand: Tocris Bioscience
SKU: 3039

Tocris Bioscience, part of Bio-Techne | Catalog # 3039

COA / SDS

ACAT inhibitor

Discontinued Product

3039 has been discontinued. View all Acyl-CoA:Cholesterol Acyltransferase Inhibitors products.

Key Product Details

Description:	ACAT inhibitor
Chemical Name:	N-Cycloheptyl-N-(9H-fluoren-2-ylmethyl)-N'-(2,4,6-trimethylphenyl)urea
Purity:	≥98% (HPLC)
Molecular Weight:	452.63

View Full Technical Details for YM 750

Technical Data
Citations

Biological Activity for YM 750

YM 750 is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor (IC₅₀ = 0.18 μM). Exhibits hypocholesterolaemic and antiatherosclerotic activity in vivo.

Licensing Information

Sold with the permission of Astellas Pharma Inc.

Technical Data for YM 750

M. Wt	452.63
Formula	C₃₁H₃₆N₂O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	138046-43-2
PubChem ID	9911716
InChi Key	FMLJREWZCZHGGW-UHFFFAOYSA-N
Smiles	O=C(NC5=C(C)C=C(C)C=C5C)N(C4CCCCCC4)CC3=CC2=C(C=C3)C1=CC=CC=C1C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for YM 750

References are publications that support the biological activity of the product.

Kamiya Bioavailable acyl-CoA: cholesterol acyltransferase inhibitor with anti-peroxidative activity: synthesis and biological activity of novel indolinyl amide and urea derivatives. Chem.Pharm.Bull. 2000 PMID: 10866142
Miike Effects of an anti-oxidative ACAT inhibitor on apoptosis/necrosis and cholesterol accumulation under oxidative stress in THP-1 cell dervied foam cells. Life Sci. 2008 PMID: 18037448
Nagata N-[2-[N'-pentyl-(6,6-dimethyl-2,4-heptadiynyl)amino]ethyl]-(2-methyl-1-naphthylthio)acetamide (FY-087). A new acyl coenzyme A: cholesterol acyltransferase (ACAT) inhibitor of diet-induced atherosclerosis formation in mice. Biochem.Pharmacol. 1995 PMID: 7887979