YM 244769

Tocris Bioscience, part of Bio-Techne | Catalog # 4544

Na+/Ca2+ exchange inhibitor (reverse mode); neuroprotective
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Key Product Details

Description

Na+/Ca2+ exchange inhibitor (reverse mode); neuroprotective

View all Na+/Ca2+ Exchanger Inhibitors »

Product Description

YM 244769 is an inhibitor of the reverse mode of Na+/Ca2+ exchange (NCX). Potently inhibits Na+-dependent 45Ca2+ uptake (IC50 values are 18, 68 and 96 nM for CCL39 cells transfected with NCX3, NCX1 and NCX2 respectively). Displays selectivity for NCX over other Na+ and Ca2+ transporters. Protects against hypoxia/reoxygenation-induced cell damage in neuronal SH-SY5Y cells expressing NCX1 and NCX3.

Product Specifications

Molecular Weight

516.39

Formula

C26H22FN3O3.2HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

N-[(3-Aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-3-pyridinecarboxamide dihydrochloride

CAS Number

1780390-65-9

PubChem ID

90488952

InChI Key

OCKIUNLKEPKCRE-UHFFFAOYSA-N

SMILES

NC1=CC=CC(CNC(C2=CN=C(OC3=CC=C(OCC4=CC=CC(F)=C4)C=C3)C=C2)=O)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.64 100

Preparing Stock Solutions for YM 244769

The following data is based on the product molecular weight 516.39

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.94 mL 9.68 mL 19.37 mL
5 mM 0.39 mL 1.94 mL 3.87 mL
10 mM 0.19 mL 0.97 mL 1.94 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for YM 244769

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for YM 244769

For research use only

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