YE 120

Tocris Bioscience, part of Bio-Techne | Catalog # 4457

COA / SDS

GPR35 agonist

Key Product Details

Description:	GPR35 agonist
Chemical Name:	2-[3-Cyano-5-(3,4-dichlorophenyl)-4,5-dimethyl-2(5H)-furanylidene]propanedinitrile
Purity:	≥98% (HPLC)
Molecular Weight:	330.17

View Full Technical Details for YE 120

Technical Data
Citations

Biological Activity for YE 120

YE 120 is a GPR35 agonist (EC₅₀ = 32 nM in DMR assays). Also displays partial agonist activity in a β-arrestin translocation assay (EC₅₀ = 10.2 μM).

Compound Libraries for YE 120

YE 120 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for YE 120

M. Wt	330.17
Formula	C₁₆H₉Cl₂N₃O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	383124-82-1
PubChem ID	12138435
InChi Key	RSWZFAPYKOARNG-UHFFFAOYSA-N
Smiles	CC(C(C2=CC=C(Cl)C(Cl)=C2)(C)O1)=C(C#N)/C1=C(C#N)\C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for YE 120

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	33.02	100

Preparing Stock Solutions for YE 120

The following data is based on the product molecular weight 330.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.03 mL	15.14 mL	30.29 mL
5 mM	0.61 mL	3.03 mL	6.06 mL
10 mM	0.30 mL	1.51 mL	3.03 mL
50 mM	0.06 mL	0.30 mL	0.61 mL

Molarity Calculator

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Reconstitution Calculator

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References for YE 120

References are publications that support the biological activity of the product.

Deng Discovery of 2-(4-methylfuran-2(5H)-ylidene)malononitrile and thieno[3,2-b]thiophene-2-carboxylic acid derivatives as G protein-coupled receptor 35 (GPR35) agonists. J.Med.Chem. 2011 PMID: 21950657