Y-25130 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 0380
Potent and selective 5-HT3 antagonist
Discontinued Product
0380 has been discontinued.
View all 5-HT3 Receptor Antagonists products.
Key Product Details
Description
Potent and selective 5-HT3 antagonist
Product Description
Y-25130 hydrochloride is a selective and potent 5-HT3 antagonist (Ki = 2.9 nM).Product Specifications
Molecular Weight
386.28
Formula
C17H20ClN3O3.HCl
Storage
Desiccate at -20°C
Purity
≥99% (HPLC)
Chemical Name
N-(1-Azabicyclo[2.2.2]oct-3-yl)-6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide hydrochloride
CAS Number
123040-16-4
PubChem ID
115000
InChI Key
DBMKBKPJYAHLQP-UHFFFAOYSA-N
SMILES
Cl.CN1C(=O)COC2=C(C=C(Cl)C=C12)C(=O)NC1CN2CCC1CC2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 100 | ||
| DMSO | 3.86 | 10 |
Preparing Stock Solutions
for Y-25130 hydrochloride
The following data is based on the product molecular weight 386.28
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.59 mL | 12.94 mL | 25.89 mL |
| 5 mM | 0.52 mL | 2.59 mL | 5.18 mL |
| 10 mM | 0.26 mL | 1.29 mL | 2.59 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Haga The effects of orally administered Y-25130, a selective serotonin3 receptor antagonist on chemotherapeutic agent-induced emesis. Jpn.J.Pharmacol. 1993 PMID: 8107329
- Sato Antagonistic activity of Y-25130 on 5-HT3 receptors. Jpn.J.Pharmacol. 1992 PMID: 1331590
- Fukuda The antiemetic profile of Y-25130, a new selective 5-HT3 receptor antagonist. Eur.J.Pharmacol. 1991 PMID: 1654255
Product Specific Notices for Y-25130 hydrochloride
For research use only
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