XY 018
Tocris Bioscience, part of Bio-Techne | Catalog # 6223
RORγ antagonist; inhibits AR expression
Key Product Details
Description
RORγ antagonist; inhibits AR expression
Product Description
XY 018 is a RORγ antagonist (EC50 = 190 nM). Suppresses androgen receptor expression in prostate cancer cell lines. Also inhibits growth of tumors in androgen receptor-positive xenograft models.Product Specifications
Molecular Weight
516.36
Formula
C23H15F7N2O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[2'-Fluoro-4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'biphenyl]-4-yl]-2-nitrobenzeneacetamide
CAS Number
1873358-87-2
PubChem ID
130248006
InChI Key
MNVXADPCMINSEC-UHFFFAOYSA-N
SMILES
OC(C(F)(F)F)(C(F)(F)F)C1=CC(F)=C(C2=CC=C(C=C2)NC(CC3=C([N+]([O-])=O)C=CC=C3)=O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 51.64 | 100 | |
| Ethanol | 51.64 | 100 |
Preparing Stock Solutions
for XY 018
The following data is based on the product molecular weight 516.36
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.94 mL | 9.68 mL | 19.37 mL |
| 5 mM | 0.39 mL | 1.94 mL | 3.87 mL |
| 10 mM | 0.19 mL | 0.97 mL | 1.94 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.39 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ndagi Re-emergence of an orphan therapeutic target for the treatment of resistant prostate cancer - a through conformational and binding analysis for RORγ protein. J.Biomol.Struct.Dyn. 2018 PMID: 28027708
- Wang ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. Nat.Med. 2016 PMID: 27019329
Product Specific Notices for XY 018
For research use only
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