XY 018

Name: XY 018
Brand: Tocris Bioscience
SKU: 6223

Tocris Bioscience, part of Bio-Techne | Catalog # 6223

Citations (2)

COA / SDS

RORγ antagonist; inhibits AR expression

Key Product Details

Description:	RORγ antagonist; inhibits AR expression
Chemical Name:	N-[2'-Fluoro-4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'biphenyl]-4-yl]-2-nitrobenzeneacetamide
Purity:	≥98% (HPLC)
Molecular Weight:	516.36

View Full Technical Details for XY 018

Technical Data
Citations

Biological Activity for XY 018

XY 018 is a RORγ antagonist (EC₅₀ = 190 nM). Suppresses androgen receptor expression in prostate cancer cell lines. Also inhibits growth of tumors in androgen receptor-positive xenograft models.

Compound Libraries for XY 018

XY 018 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for XY 018

M. Wt	516.36
Formula	C₂₃H₁₅F₇N₂O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1873358-87-2
PubChem ID	130248006
InChi Key	MNVXADPCMINSEC-UHFFFAOYSA-N
Smiles	OC(C(F)(F)F)(C(F)(F)F)C1=CC(F)=C(C2=CC=C(C=C2)NC(CC3=C([N+]([O-])=O)C=CC=C3)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for XY 018

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	51.64	100
	ethanol	51.64	100

Preparing Stock Solutions for XY 018

The following data is based on the product molecular weight 516.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.94 mL	9.68 mL	19.37 mL
5 mM	0.39 mL	1.94 mL	3.87 mL
10 mM	0.19 mL	0.97 mL	1.94 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

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References for XY 018

References are publications that support the biological activity of the product.

Ndagi Re-emergence of an orphan therapeutic target for the treatment of resistant prostate cancer - a through conformational and binding analysis for RORγ protein. J.Biomol.Struct.Dyn. 2018 PMID: 28027708
Wang ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. Nat.Med. 2016 PMID: 27019329