XCT 790

Name: XCT 790
Brand: Tocris Bioscience
SKU: 3928

Tocris Bioscience, part of Bio-Techne | Catalog # 3928

Citations (15)

COA / SDS

Selective ERRα inverse agonist

Key Product Details

Description:	Selective ERRα inverse agonist
Chemical Name:	3-[4-(2,4-Bis-trifluoromethylbenzyloxy)-3-methoxyphenyl]-2-cyano-N-(5-trifluoromethyl-1,3,4-thiadiazol-2-yl)acrylamide
Purity:	≥98% (HPLC)
Molecular Weight:	596.42

View Full Technical Details for XCT 790

Technical Data
Citations

Biological Activity for XCT 790

XCT 790 is a selective ERRα inverse agonist (IC₅₀ = ~400 nM). Displays no antagonist activity at ERRγ or ERα at concentrations below 10 μM. Interferes with PPARγ coactivator-1α (PGC-1α)/ERRα-dependent signaling: inhibits PGC-1α induction of ERRα and MAO-B gene expression and downregulates the constitutive transcriptional activity of ERRα in numerous cell lines.

Technical Data for XCT 790

M. Wt	596.42
Formula	C₂₃H₁₃F₉N₄O₃S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	725247-18-7
PubChem ID	6918788
InChi Key	HQFNFOOGGLSBBT-AWNIVKPZSA-N
Smiles	O=C(NC3=NN=C(C(F)(F)F)S3)/C(C#N)=C/C(C=C2OC)=CC=C2OCC1=C(C(F)(F)F)C=C(C(F)(F)F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for XCT 790

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	5.96	10 with gentle warming

Preparing Stock Solutions for XCT 790

The following data is based on the product molecular weight 596.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.77 mL	83.83 mL	167.67 mL
0.5 mM	3.35 mL	16.77 mL	33.53 mL
1 mM	1.68 mL	8.38 mL	16.77 mL
5 mM	0.34 mL	1.68 mL	3.35 mL

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References for XCT 790

References are publications that support the biological activity of the product.

Theodoris Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease. Science. 2021 PMID: 33303684
Kong Peroxisome proliferator-activated receptor γ coactivator-1α enhances antiproliferative activity of 5'-deoxy-5-fluorouridine in cancer cells through induction of uridine phosphorylase. Mol.Pharmacol. 2009 PMID: 19602572
Willy Regulation of PPARγ coactivator 1α (PGC-1α) signaling by an estrogen-related receptor alpha (ERRα) ligand. Proc.Natl.Acad.Sci.USA
Lanvin Potentiation of ICI182,780 (Fulvestrant)-induced estrogen receptor-alpha degradation by the estrogen receptor-related receptor-α inverse agonist XCT790. J.Biol.Chem. 2007 PMID: 17631492