WZB 117

Tocris Bioscience, part of Bio-Techne | Catalog # 6143

COA / SDS

GLUT inhibitor

Key Product Details

Description:	GLUT inhibitor
Chemical Name:	3-Fluoro-1,2-phenylene bis(3-hydroxybenzoate)
Purity:	≥98% (HPLC)
Molecular Weight:	368.31

View Full Technical Details for WZB 117

Technical Data
Citations

Biological Activity for WZB 117

WZB 117 is a GLUT inhibitor (K_i(app) values are 0.2, 10 and 10 μM for GLUT4, GLUT1 and GLUT3, respectively). Competitive inhibitor of net glucose uptake but a noncompetitive inhibitor of sugar efflux from cells. Inhibits passive sugar transport in human erythrocytes and cancer cell lines. Attenuates erythrocyte 3-O-methylglucose (3MG) uptake in vitro (K_i = 6 μM). Suppresses tumor growth in a nude mouse model.

Compound Libraries for WZB 117

WZB 117 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for WZB 117

M. Wt	368.31
Formula	C₂₀H₁₃FO₆
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1223397-11-2
PubChem ID	46830365
InChi Key	FRSWCCBXIHFKKY-UHFFFAOYSA-N
Smiles	OC1=CC=CC(C(OC2=C(C(F)=CC=C2)OC(C3=CC(O)=CC=C3)=O)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for WZB 117

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	36.83	100
	ethanol	36.83	100

Preparing Stock Solutions for WZB 117

The following data is based on the product molecular weight 368.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.72 mL	13.58 mL	27.15 mL
5 mM	0.54 mL	2.72 mL	5.43 mL
10 mM	0.27 mL	1.36 mL	2.72 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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References for WZB 117

References are publications that support the biological activity of the product.

Liu A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo. Mol.Cancer Ther. 2012 PMID: 22689530
Koch Glucose transporter isoform 1 expression enhances metastasis of malignant melanoma cells. Oncotarget 2015 PMID: 26293674
Ojelabi WZB117 (2-Fluoro-6-(m-hydroxybenzoyloxy) Phenyl m-Hydroxybenzoate) inhibits GLUT1-mediated sugar transport by binding reversibly at the exofacial sugar binding site. J.Biol.Chem. 2016 PMID: 27836974