WZ 4002
Tocris Bioscience, part of Bio-Techne | Catalog # 6290
Potent mutant-selective EGFR inhibitor
Key Product Details
Description
Potent mutant-selective EGFR inhibitor
Product Description
WZ 4002 is a potent irreversible mutant selective EGFR tyrosine kinase inhibitor. It blocks ATP-dependent autophosphorylation of EGFR carrying the T790M or L858R mutation (IC50 = 8 nM). WZ 4002 exhibits selectivity for mutant EGFR over wild-type. In mice bearing T790M mutant lung cancer cell lines WZ 4002 inhibits EGFR, AKT and ERK1/2 phosphorylation and results in significant tumor regression.Licensing Information
Sold under license from Dana-Farber Cancer Institute.Product Specifications
Molecular Weight
494.98
Formula
C25H27ClN6O3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide
CAS Number
1213269-23-8
PubChem ID
44607530
InChI Key
ITTRLTNMFYIYPA-UHFFFAOYSA-N
SMILES
COC1=C(NC2=NC=C(Cl)C(OC3=CC(NC(C=C)=O)=CC=C3)=N2)C=CC(N4CCN(C)CC4)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.95 | 10 |
Preparing Stock Solutions
for WZ 4002
The following data is based on the product molecular weight 494.98
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.20 mL | 101.01 mL | 202.03 mL |
| 0.5 mM | 4.04 mL | 20.20 mL | 40.41 mL |
| 1 mM | 2.02 mL | 10.10 mL | 20.20 mL |
| 5 mM | 0.40 mL | 2.02 mL | 4.04 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zhou Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature 2009 PMID: 20033049
Product Specific Notices for WZ 4002
For research use only
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