WS 12
Tocris Bioscience, part of Bio-Techne | Catalog # 3040
TRPM8 agonist; cooling agent
Product Description
WS 12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 = 193 nM).Product Specifications
Molecular Weight
289.41
Formula
C18H27NO2
Storage
Store at -20°C
Purity
≥99% (HPLC)
Chemical Name
(1R*,2S*)-N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide
CAS Number
68489-09-8
PubChem ID
11266244
InChI Key
HNSGVPAAXJJOPQ-XOKHGSTOSA-N
SMILES
C[C@H](C)[C@H]1[C@H]([C@@](NC2=CC=C(OC)C=C2)=O)C[C@H](C)CC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| Ethanol | 21.71 | 75 |
Preparing Stock Solutions
for WS 12
The following data is based on the product molecular weight 289.41
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.75 mM | 4.61 mL | 23.04 mL | 46.07 mL |
| 3.75 mM | 0.92 mL | 4.61 mL | 9.21 mL |
| 7.5 mM | 0.46 mL | 2.30 mL | 4.61 mL |
| 37.5 mM | 0.09 mL | 0.46 mL | 0.92 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Bodding Characterisation of TRPM8 as a pharmacophore receptor. Cell Calcium 2007 PMID: 17517434
- Beck Prospects for prostate cancer imaging and therapy using high-affinity TRPM8 activators. Cell Calcium 2007 PMID: 16949669
Product Specific Notices for WS 12
For research use only
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