WM 8014
Tocris Bioscience, part of Bio-Techne | Catalog # 6693
Potent and selective KAT6A and KAT6B inhibitor
Key Product Details
Description
Potent and selective KAT6A and KAT6B inhibitor
Product Description
WM 8014 is a potent and selective lysine acetyltransferase KAT6A and KAT6B inhibitor (IC50 values are 8 and 28 nM, respectively). Exhibits > 10-fold selectivity for KAT6A/B over KAT7 and KAT5, and no significant activity against KAT8, KAT2A/2B, and KAT3A/B. Induces cell cycle arrest in G1/G0 in MEFs and inhibits proliferation of lymphoma cells in vitro. Cell permeant. Suitable for use in vitro.Licensing Information
Sold under license from Monash UniversityProduct Specifications
Molecular Weight
384.42
Formula
C20H17FN2O3S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N'-(4-Fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)benzenesulfonohydrazide
CAS Number
2055397-18-5
PubChem ID
133053564
InChI Key
PHHZKBMVRPULAW-UHFFFAOYSA-N
SMILES
CC1=CC(C2=CC=CC=C2)=CC(C(NNS(=O)(C3=CC=CC=C3)=O)=O)=C1F
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.69 | 20 | |
| Ethanol | 3.84 | 10 |
Preparing Stock Solutions
for WM 8014
The following data is based on the product molecular weight 384.42
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 13.01 mL | 65.03 mL | 130.07 mL |
| 1 mM | 2.60 mL | 13.01 mL | 26.01 mL |
| 2 mM | 1.30 mL | 6.50 mL | 13.01 mL |
| 10 mM | 0.26 mL | 1.30 mL | 2.60 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Baell Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth. Nature 2018 PMID: 30069049
Product Specific Notices for WM 8014
For research use only
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