WM 1119
Tocris Bioscience, part of Bio-Techne | Catalog # 6692
High affinity KAT6A (MOZ) competitive inhibitor
Key Product Details
Description
High affinity KAT6A (MOZ) competitive inhibitor
Product Description
WM 1119 is a high affinity and competitive lysine acetyltransferase 6A (KAT6A/MOZ) inhibitor (Kd = 2 nM), which displays >250-fold affinity for KAT6A compared to KAT5 and KAT7. WM 1119 induces cell-cycle exit and cellular senescence, and inhibits growth of B-cell lymphoma cells in vitro (IC50 = 0.25 μM). WM 1119 also reduces H3K9ac in tumor cells, and decreases tumor burden and spleen weight in a mouse lymphoma model.Licensing Information
Sold under license from Monash UniversityExternal Portal Information
Chemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of WM 1119 is reviewed on chemicalprobes.org and the SGC website.Product Specifications
Molecular Weight
389.38
Formula
C18H13F2N3O3S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-Fluoro-N'-(3-fluoro-5-(pyridin-2-yl)benzoyl)benzenesulfonohydrazide
CAS Number
2055397-28-7
PubChem ID
133080719
InChI Key
QLXULUNLCRKWRD-UHFFFAOYSA-N
SMILES
FC1=CC(C2=CC=CC=N2)=CC(C(NNS(=O)(C3=C(C=CC=C3)F)=O)=O)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.94 | 100 |
Preparing Stock Solutions
for WM 1119
The following data is based on the product molecular weight 389.38
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.57 mL | 12.84 mL | 25.68 mL |
| 5 mM | 0.51 mL | 2.57 mL | 5.14 mL |
| 10 mM | 0.26 mL | 1.28 mL | 2.57 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.51 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Baell Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth. Nature. 2018 PMID: 30069049
Product Specific Notices for WM 1119
For research use only
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