WM 1119

Name: WM 1119
Brand: Tocris Bioscience
SKU: 6692

Tocris Bioscience, part of Bio-Techne | Catalog # 6692

Citations (5)

COA / SDS

High affinity KAT6A (MOZ) competitive inhibitor

Key Product Details

Description:	High affinity KAT6A (MOZ) competitive inhibitor
Chemical Name:	2-Fluoro-N'-(3-fluoro-5-(pyridin-2-yl)benzoyl)benzenesulfonohydrazide
Purity:	≥98% (HPLC)
Molecular Weight:	389.38

View Full Technical Details for WM 1119

Technical Data
Citations

Biological Activity for WM 1119

WM 1119 is a high affinity and competitive lysine acetyltransferase 6A (KAT6A/MOZ) inhibitor (K_d = 2 nM), which displays >250-fold affinity for KAT6A compared to KAT5 and KAT7. WM 1119 induces cell-cycle exit and cellular senescence, and inhibits growth of B-cell lymphoma cells in vitro (IC₅₀ = 0.25 μM). WM 1119 also reduces H3K9ac in tumor cells, and decreases tumor burden and spleen weight in a mouse lymphoma model.

Licensing Information

Sold under license from Monash University

Compound Libraries for WM 1119

WM 1119 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

External Portal Information

Chemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of WM 1119 is reviewed on chemicalprobes.org and the SGC website.

Technical Data for WM 1119

M. Wt	389.38
Formula	C₁₈H₁₃F₂N₃O₃S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	2055397-28-7
PubChem ID	133080719
InChi Key	QLXULUNLCRKWRD-UHFFFAOYSA-N
Smiles	FC1=CC(C2=CC=CC=N2)=CC(C(NNS(=O)(C3=C(C=CC=C3)F)=O)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for WM 1119

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	38.94	100

Preparing Stock Solutions for WM 1119

The following data is based on the product molecular weight 389.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.57 mL	12.84 mL	25.68 mL
5 mM	0.51 mL	2.57 mL	5.14 mL
10 mM	0.26 mL	1.28 mL	2.57 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

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References for WM 1119

References are publications that support the biological activity of the product.

Baell Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth. Nature. 2018 PMID: 30069049