WKYMVm

Tocris Bioscience, part of Bio-Techne | Catalog # 1800

Citations (73)

COA / SDS

FPR1, FPR2 and FPR3 receptor agonist

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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

FPR1, FPR2 and FPR3 receptor agonist

Alternative Names

Leukocyte chemoattractant peptide

View all Formyl Peptide Receptor Agonists »

Product Description

WKYMVm is a selective agonist for the formyl peptide receptors FPR1, FPR2 (EC₅₀ = 75 pM) and FPR3 (EC₅₀ = 3 nM), expressed on immune cells. Induces Ca²⁺ mobilization and superoxide production in, and chemotaxic migration of, monocytes and neutrophils. Also promotes monocyte survival through a PKC-, PI 3-kinase- and Akt-dependent pathway.

Product Specifications

Molecular Weight

856.11

Formula

C₄₁H₆₁N₉O₇S₂

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

187986-17-0

PubChem ID

457933

InChI Key

FMBGOORJEKQQLG-JUZZZACGSA-N

SMILES

[H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 2mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product.

Christophe The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH₂ specifically activates neutrophils through FPRL1/Lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. J.Biol.Chem. 2001 PMID: 11285256
Le Utilization of two seven-transmembrane, G protein-coupled receptors, formyl peptide receptor-like 1 and fomyl peptide receptor, by the synthetic hexapeptide WKYMVm for human phagocyte activation. J.Immunol. 1999 PMID: 10586077
Bae The synthetic chemoattractant peptide, Trp-Lys-Tyr-Met-Val-D-Met, enhances monocyte survival via PKC-dependent Akt activation. J.Leukoc.Biol. 2002 PMID: 11818455