WIN 18446

Name: WIN 18446
Brand: Tocris Bioscience
SKU: 4736
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4736

(1)

Citations (9)

COA / SDS

ALDH1A2 inhibitor

Key Product Details

Description:	ALDH1A2 inhibitor
Chemical Name:	N,N'-1,8-Octanediylbis(2,2-dichloroacetamide)
Molecular Weight:	366.11

View Full Technical Details for WIN 18446

Technical Data
Citations / Reviews (1)

Biological Activity for WIN 18446

WIN 18446 is an inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2) (IC₅₀ = 0.3 μM). Inhibits the biosynthesis of retinoic acid from retinol in neonatal and adult murine testis.

Technical Data for WIN 18446

M. Wt	366.11
Formula	C₁₂H₂₀Cl₄N₂O₂
Storage	Store at +4°C
CAS Number	1477-57-2
PubChem ID	15134
InChi Key	FAOMZVDZARKPFJ-UHFFFAOYSA-N
Smiles	ClC(Cl)C(NCCCCCCCCNC(C(Cl)Cl)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for WIN 18446

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	36.61	100

Preparing Stock Solutions for WIN 18446

The following data is based on the product molecular weight 366.11.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.73 mL	13.66 mL	27.31 mL
5 mM	0.55 mL	2.73 mL	5.46 mL
10 mM	0.27 mL	1.37 mL	2.73 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

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Reconstitution Calculator

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References for WIN 18446

References are publications that support the biological activity of the product.

Hogarth Suppression of Stra8 expression in the mouse gonad by WIN 18,446. Biol.Reprod. 2011 PMID: 21209416
Amory Suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis. J.Androl. 2011 PMID: 20705791