WIKI4
Tocris Bioscience, part of Bio-Techne | Catalog # 4855
Potent tankyrase inhibitor
Product Description
WIKI4 is an inhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM). Inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM); prevents the ubiquitination and degradation of axin. WIKI4 inhibits expression of β-catenin target genes in cancer cell lines as well as in human embryonic stem cells (ESC).Product Specifications
Molecular Weight
521.59
Formula
C29H23N5O3S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-[3-[[4-(4-Methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-1H-benz[de]isoquinoline-1,3(2H)-dione
CAS Number
838818-26-1
PubChem ID
2984337
InChI Key
RNUXIZKXJOGYQP-UHFFFAOYSA-N
SMILES
O=C(C5=C4C(C6=O)=CC=CC4=CC=C5)N6CCCSC1=NN=C(C3=CC=NC=C3)N1C2=CC=C(OC)C=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.22 | 10 |
Preparing Stock Solutions
for WIKI4
The following data is based on the product molecular weight 521.59
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.17 mL | 95.86 mL | 191.72 mL |
| 0.5 mM | 3.83 mL | 19.17 mL | 38.34 mL |
| 1 mM | 1.92 mL | 9.59 mL | 19.17 mL |
| 5 mM | 0.38 mL | 1.92 mL | 3.83 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- James WIKI4, a novel inhibitor of tankyrase and Wnt/β-catenin signaling. PLoS One 2012 PMID: 23227175
Product Specific Notices for WIKI4
For research use only
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