WIC1
Tocris Bioscience, part of Bio-Techne | Catalog # 7580
Inhibitor of Wnt/β-catenin signaling
Key Product Details
Description
Inhibitor of Wnt/β-catenin signaling
Product Description
WIC1 is an inhibitor of the canonical Wnt/β-catenin signaling pathway. In vitro, it reduces ABSC (Airway Basal Stem Cell) proliferation and induces ciliated epithelial cell differentiation, in a model of squamous lung cancer. WIC1 also represses the phosphorylation of β-cateninY489 and Tp63 expression.Product Specifications
Molecular Weight
377.44
Formula
C22H23N3O3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[4-(4-Ethyl-1-piperazinyl)phenyl]-2-oxo-2H-1-benzopyran-3-carboxamide
CAS Number
943083-58-7
PubChem ID
24746859
InChI Key
YQXKWSNLAVFZJL-UHFFFAOYSA-N
SMILES
CCN1CCN(C2=CC=C(C=C2)NC(C3=CC4=CC=CC=C4OC3=O)=O)CC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 0.75 | 2 with gentle warming |
Preparing Stock Solutions
for WIC1
The following data is based on the product molecular weight 377.44
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.02 mM | 132.47 mL | 662.36 mL | 1,324.71 mL |
| 0.1 mM | 26.49 mL | 132.47 mL | 264.94 mL |
| 0.2 mM | 13.25 mL | 66.24 mL | 132.47 mL |
| 1 mM | 2.65 mL | 13.25 mL | 26.49 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Aros High-throughput drug screening identifies a potent Wnt inhibitor that promotes airway basal stem cell homeostasis. Cell Rep. 2020 PMID: 32075752
Product Specific Notices for WIC1
For research use only
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