WDR5 0103
Tocris Bioscience, part of Bio-Techne | Catalog # 5323
WDR5 antagonist
Product Description
WDR5 0103 is a WD repeat-containing protein 5 (WDR5) antagonist (Kd = 450 nM). Disrupts WDR5 interaction with MLL and inhibits MLL core complex methyltransferase activity in vitro. Has no effect on a panel of seven other methyltransferases, including SETD7.Product Specifications
Molecular Weight
383.44
Formula
C21H25N3O4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
3-[(3-Methoxybenzoyl)amino]-4-(4-methyl-1-piperazinyl)benzoic acid methyl ester
CAS Number
890190-22-4
PubChem ID
6457069
InChI Key
ZPLBXOVTSNRBFB-UHFFFAOYSA-N
SMILES
O=C(OC)C1=CC(NC(C3=CC=CC(OC)=C3)=O)=C(N2CCN(C)CC2)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.34 | 100 | |
| Ethanol | 19.17 | 50 |
Preparing Stock Solutions
for WDR5 0103
The following data is based on the product molecular weight 383.44
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.61 mL | 13.04 mL | 26.08 mL |
| 5 mM | 0.52 mL | 2.61 mL | 5.22 mL |
| 10 mM | 0.26 mL | 1.30 mL | 2.61 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Senisterra Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. Biochem.J. 2013 PMID: 22989411
Product Specific Notices for WDR5 0103
For research use only
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