WAY 170523
Tocris Bioscience, part of Bio-Techne | Catalog # 2633
Potent and selective inhibitor of MMP-13
Key Product Details
Description
Potent and selective inhibitor of MMP-13
Product Description
WAY 170523 is a potent and selective inhibitor of MMP-13 (IC50 values are 17, 945, > 1000 and > 10000 nM for MMP-13, MMP-9, TACE and MMP-1 respectively).Product Specifications
Molecular Weight
613.68
Formula
C33H31N3O7S
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
N-[2-[4-[[[2-[(Hydroxyamino)carbonyl]-4,6-dimethylphenyl](phenylmethyl)amino]sulfonyl]phenoxy]ethyl]-2-benzofurancarboxamide
CAS Number
307002-73-9
PubChem ID
9830392
InChI Key
FARMEEAGJWMFSZ-UHFFFAOYSA-N
SMILES
CC1=CC(C(=O)NO)=C(N(CC2=CC=CC=C2)S(=O)(=O)C2=CC=C(OCCNC(=O)C3=CC4=CC=CC=C4O3)C=C2)C(C)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 61.37 | 100 | |
| Ethanol | 61.37 | 100 |
Preparing Stock Solutions
for WAY 170523
The following data is based on the product molecular weight 613.68
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.63 mL | 8.15 mL | 16.30 mL |
| 5 mM | 0.33 mL | 1.63 mL | 3.26 mL |
| 10 mM | 0.16 mL | 0.81 mL | 1.63 mL |
| 50 mM | 0.03 mL | 0.16 mL | 0.33 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Jaffré beta-adrenergic receptor stimulation transactivates protease-activated receptor 1 via matrix metalloproteinase 13 in cardiac cells. Circulation 2012 PMID: 22610965
- Chen Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design. J.Am.Chem.Soc.
Product Specific Notices for WAY 170523
For research use only
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