VUF 8430 dihydrobromide
Tocris Bioscience, part of Bio-Techne | Catalog # 2494
Potent and high affinity H4 agonist
Discontinued Product
2494 has been discontinued.
View all Histamine H4 Receptor Agonists products.
Key Product Details
Description
Potent and high affinity H4 agonist
Product Description
VUF 8430 dihydrobromide is a high affinity (pKi = 7.5), potent histamine H4 receptor full agonist (pEC50 = 7.3). Displays moderate affinity for H3 receptors (pKi = 6.0) and weak partial agonist activity at H2 receptors.Product Specifications
Molecular Weight
323.05
Formula
C4H11N5S.2HBr
Storage
Desiccate at RT
Chemical Name
2-[(Aminoiminomethyl)amino]ethyl carbamimidothioic acid ester dihydrobromide
CAS Number
100130-32-3
PubChem ID
3063227
InChI Key
GPWJSTKHQMIXCA-UHFFFAOYSA-N
SMILES
Br.Br.NC(SCCNC(N)=N)=N
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 32.31 | 100 | |
| DMSO | 32.31 | 100 |
Preparing Stock Solutions
for VUF 8430 dihydrobromide
The following data is based on the product molecular weight 323.05
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.10 mL | 15.48 mL | 30.95 mL |
| 5 mM | 0.62 mL | 3.10 mL | 6.19 mL |
| 10 mM | 0.31 mL | 1.55 mL | 3.10 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Lim Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist. J.Med.Chem. 2006 PMID: 17154494
- Lim Phenylalanine 169 in the second extracellular loop of the human histamine H4 receptor is responsible for the difference in agonist binding between human and mouse H4 receptors. J.Pharmacol.Exp.Ther. 2008 PMID: 18635748
- Sterk The influence of guanidio and isothiourea groups in histaminergic compounds on H2-activity. Agents Actions 1986 PMID: 2942013
Product Specific Notices for VUF 8430 dihydrobromide
For research use only
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