VU 6019650
Tocris Bioscience, part of Bio-Techne | Catalog # 8055
M5 receptor antagonist
Product Description
VU 6019650 is a potent and selective M5 receptor antagonist (hM5 IC50 = 36 nM). Exhibits >100-fold selectivity over human and rat M1-4. In vivo, VU 6019650 inhibits the reward effects of oxycodone and reduces oxycodone self-administration in rats. VU 6019650 is blood brain barrier penetrant.Licensing Information
Sold under license from Vanderbilt UniversityProduct Specifications
Molecular Weight
411.51
Formula
C18H22FN3O3S2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(3R,4S)-rel-1-[(2,3-Dihydro-5-benzofuranyl)sulfonyl]-3-fluoro-4-[[(1-methyl-1H-imidazol-2-yl)thio]methyl]piperidine
CAS Number
2926782-31-0
PubChem ID
164673826
InChI Key
MWXZKSDFCSPEBK-ZBFHGGJFSA-N
SMILES
O=S(C1=CC=C(OCC2)C2=C1)(N3C[C@@H]([C@H](CC3)CSC4=NC=CN4C)F)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.58 | 50 |
Preparing Stock Solutions
for VU 6019650
The following data is based on the product molecular weight 411.51
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.86 mL | 24.30 mL | 48.60 mL |
| 2.5 mM | 0.97 mL | 4.86 mL | 9.72 mL |
| 5 mM | 0.49 mL | 2.43 mL | 4.86 mL |
| 25 mM | 0.10 mL | 0.49 mL | 0.97 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Capstick Discovery of a potent M5 antagonist with improved clearance profile. Part 1: Piperidine amide-based antagonists. Bioorg.Med.Chem.Lett. 2022 PMID: 36113671
- Garrison Development of VU6019650: a potent, highly selective, and systemically active orthosteric antagonist of the M5 muscarinic acetylcholine receptor for the treatment of opioid use disorder. J.Med.Chem. 2022 PMID: 35417155
Product Specific Notices for VU 6019650
For research use only
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