VU 6019650

Name: VU 6019650
Brand: Tocris Bioscience
SKU: 8055

Tocris Bioscience, part of Bio-Techne | Catalog # 8055

COA / SDS

M5 receptor antagonist

Key Product Details

Description:	M₅ receptor antagonist
Chemical Name:	(3R,4S)-rel-1-[(2,3-Dihydro-5-benzofuranyl)sulfonyl]-3-fluoro-4-[[(1-methyl-1H-imidazol-2-yl)thio]methyl]piperidine
Purity:	≥98% (HPLC)
Molecular Weight:	411.51

View Full Technical Details for VU 6019650

Technical Data
Citations

Biological Activity for VU 6019650

VU 6019650 is a potent and selective M₅ receptor antagonist (hM₅ IC₅₀ = 36 nM). Exhibits >100-fold selectivity over human and rat M_1-4. In vivo, VU 6019650 inhibits the reward effects of oxycodone and reduces oxycodone self-administration in rats. VU 6019650 is blood brain barrier penetrant.

Licensing Information

Sold under license from Vanderbilt University

Technical Data for VU 6019650

M. Wt	411.51
Formula	C₁₈H₂₂FN₃O₃S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2926782-31-0
PubChem ID	164673826
InChi Key	MWXZKSDFCSPEBK-ZBFHGGJFSA-N
Smiles	O=S(C1=CC=C(OCC2)C2=C1)(N3C[C@@H]([C@H](CC3)CSC4=NC=CN4C)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for VU 6019650

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	20.58	50

Preparing Stock Solutions for VU 6019650

The following data is based on the product molecular weight 411.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.86 mL	24.30 mL	48.60 mL
2.5 mM	0.97 mL	4.86 mL	9.72 mL
5 mM	0.49 mL	2.43 mL	4.86 mL
25 mM	0.10 mL	0.49 mL	0.97 mL

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References for VU 6019650

References are publications that support the biological activity of the product.

Capstick Discovery of a potent M5 antagonist with improved clearance profile. Part 1: Piperidine amide-based antagonists. Bioorg.Med.Chem.Lett. 2022 PMID: 36113671
Garrison Development of VU6019650: a potent, highly selective, and systemically active orthosteric antagonist of the M5 muscarinic acetylcholine receptor for the treatment of opioid use disorder. J.Med.Chem. 2022 PMID: 35417155