VU 6001966
Tocris Bioscience, part of Bio-Techne | Catalog # 6928
Potent and selective negative allosteric modulator of mGlu2 receptors
Key Product Details
Description
Potent and selective negative allosteric modulator of mGlu2 receptors
Product Description
VU 6001966 is a potent and selective mGlu2 negative allosteric modulator (IC50 = 78 nM). Exhibits > 350-fold selectivity for mGlu2 over mGlu3. Also exhibits selectivity over other mGluRs and a panel of GPCRs, ion channels and transporters. VU 6001966 induces antidepression like effects in mouse models of chronic stress. CNS penetrant.Licensing Information
Sold under license from Vanderbilt UniversityProduct Specifications
Molecular Weight
326.33
Formula
C17H15FN4O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
CAS Number
2009052-76-8
PubChem ID
122539788
InChI Key
SSSNPJKQBYVHBV-UHFFFAOYSA-N
SMILES
CN1C=CC(COC2=CN=C(C(N)=O)C=C2C3=CC=C(C=C3)F)=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.63 | 100 | |
| Ethanol | 1.63 | 5 |
Preparing Stock Solutions
for VU 6001966
The following data is based on the product molecular weight 326.33
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.06 mL | 15.32 mL | 30.64 mL |
| 5 mM | 0.61 mL | 3.06 mL | 6.13 mL |
| 10 mM | 0.31 mL | 1.53 mL | 3.06 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.61 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Joffe mGlu 2 and mGlu 3 negative allosteric modulators divergently enhance thalamocortical transmission and exert rapid antidepressant-like effects. Neuron 2020 PMID: 31735403
- Bollinger Design and synthesis of mGlu2 NAMs with improved potency and CNS penetration based on a truncated picolinamide core. ACS Med.Chem.Lett. 2017 PMID: 28947937
Product Specific Notices for VU 6001966
For research use only
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