VU 590 dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 3891

Inhibitor of Kir1.1 (ROMK) and Kir7.1
Discontinued Product
3891 has been discontinued. View all Inward Rectifier Potassium Channel Blockers products.

Key Product Details

Description

Inhibitor of Kir1.1 (ROMK) and Kir7.1

View all Inward Rectifier Potassium Channel Blockers »

Product Description

VU 590 dihydrochloride is an inhibits the renal outer medullary potassium channel (Kir1.1, ROMK) (IC50 = 294 nM). Also inhibits the inward retifying K+ channel Kir7.1; displays no effect upon Kir2.1 or Kir4.1. Acts as an intracellular Kir1.1 channel pore blocker.

Product Specifications

Molecular Weight

561.46

Formula

C24H32N4O7.2HCl

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

7,13-Bis[(4-nitrophenyl)methyl]-1,4,10-trioxa-7,13-diazacyclopentadecane dihydrochloride

CAS Number

1783987-83-6

PubChem ID

71433535

InChI Key

FRYYSUBAHIUBNJ-UHFFFAOYSA-N

SMILES

O=[N+](C(C=C2)=CC=C2CN1CCOCCOCCN(CC3=CC=C([N+]([O-])=O)C=C3)CCOCC1)[O-].Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 56.15 100

Preparing Stock Solutions for VU 590 dihydrochloride

The following data is based on the product molecular weight 561.46

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.78 mL 8.91 mL 17.81 mL
5 mM 0.36 mL 1.78 mL 3.56 mL
10 mM 0.18 mL 0.89 mL 1.78 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for VU 590 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for VU 590 dihydrochloride

For research use only

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